I have seen stategy game working fine on XBOX before. CIVI evolution was great, but again not a RTS.
What im afraid of with RTS for XBOX is most the control handling. But i dont have much experience playing RTS on any console and the control handling is the main thing that keeps me away from RTS genre on console systems.
Another thing that is way better with computers vs. Consoles is the graphic and the mobility of a laptop. I personally hates the split screen when multiple players are playing on the same screen.